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Can anyone order KnowNowᵀᴹ Tests?

At the moment, KnowNowᵀᴹ Tests are for professional use only, meaning that they need to be administered by a trained healthcare professional. This means that we can take orders from organisations that have in-house or outsourced healthcare professionals who can perform the tests, or testing service providers.

However, since the KnowNowᵀᴹ Test needs just a saliva sample, it is much easier to administer effectively than other similar tests, and still return highly sensitive results. So we are investigating whether specially-trained, competent individuals could be approved to administer KnowNow tests as well.

We are also in the process of trialling and seeking approval for a variation of the KnowNow test which could be administered by individuals themselves.

What is SARS-CoV-2?

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the name given by the International Committee on Taxonomy of Viruses (ICTV) to the virus responsible for causing the disease, COVID-19.

What is a KnowNowᵀᴹ Test?

The KnowNowᵀᴹ Test is the UK's only on-the-spot COVID-19 test that uses just your saliva to tell you if you are currently able to infect someone else with COVID-19.

Unlike other tests, the KnowNowᵀᴹ Test won't give you a positive result if you have been exposed to the SARS-CoV-2 virus in the past, but are no longer able to infect other people.

Why test people who don't have symptoms?

SARS-CoV-2 is able to spread from individuals who are pre-symptomatic or asymptomatic. As a result, testing and isolation based on symptoms alone will not be sufficient to stop the spread.

This narrative review of 16 clinical studies around the globe concludes that between 40-45% of those infected with SARS-CoV-2 never develop symptoms, and that these asymptomatic carriers can infect others for an extended period, perhaps longer than 14 days.

Regular community testing with a rapid antigen test like the KnowNowᵀᴹ Test to identify asymptomatic, but infectious, individuals offers one way to break the chain of transmission and enable the re-opening of societies.

How long will it take a qualified clinician to administer each test?

From our own studies with partners, we estimate that a clinical professional can administer one test every 3.5 to 4 minutes. This assumes that they collect saliva samples from individuals, set the KnowNowᵀᴹ Test devices aside to develop for 15 minutes, and collect samples from further individuals before reading the results from earlier tests.

When did you start?

Vatic was founded in October 2019 by Alex Sheppard and Dr. Mona Kab Omir.

When the first wave of COVID-19 started in the UK in early 2020, our team immediately saw an opportunity to contribute to global efforts to tackle the pandemic, and leveraged work already underway on antigen testing to quickly start developing the KnowNowᵀᴹ Test.

What does a negative test result look like and mean?

Negative KnowNowᵀᴹ Test Result

If there is one red line visible next to the "C" in the KnowNow device test results window, and no line at all next to the "T", then the test result is negative. This indicates that no SARS-CoV-2 antigen has been detected in the sample.

How does KnowNowᵀᴹ compare to COVID-19 antibody tests?

The KnowNowᵀᴹ Test and COVID-19 antibody tests test for completely different things.

Antibody tests identify whether someone has had coronavirus in the past, whereas the KnowNowᵀᴹ Test detects whether an individual is currently infectious.

Antibody testing involves detecting the immune response in the human body to having fought off a virus. These tests look for an antibody created in the bloodstream in response to the presence of a virus in that environment. This is useful when testing the effectiveness of a vaccine, or understanding how far and wide a virus has spread. However, it is of limited usefulness to individuals, as it is only able to identify whether an individual has fought off the SARS-CoV-2 virus in the past. It cannot effectively confirm whether they are currently infected, or infectious.

How does KnowNowᵀᴹ compare to other COVID-19 lateral flow antigen tests?

The KnowNowᵀᴹ Test is unique to other lateral flow antigen tests in 3 key areas.

The first key difference is that the KnowNow test needs only a saliva sample, which can be taken easily and comfortably from the mouth. Other lateral flow antigen tests usually need a nasopharyngeal, anterior nasal or tonsil sample, all of which are painful and unpleasant for the individual being tested and more challenging to collect effectively for the clinical professional administering the test. No one wants to be made to cry or gag, or make someone else cry or gag, on a regular basis!

The second is that the KnowNowᵀᴹ Test looks specifically for live virus which would cause the individual tested to be able to infect others. Although other lateral flow antigen tests are often said to test whether an individual is infectious, this is because they have a higher Limit of Detection and can only detect the virus when there are more viral particles present in the sample. As a result, they offer a proxy measure for infectivity, rather than directly testing whether there is live virus in the sample. The KnowNowᵀᴹ Test on the other hand is a true infectiousness test, which uses a unique patented mechanism which detects a completely different part of the virus.

Finally, the KnowNowᵀᴹ Test is also more sensitive than other rapid antigen tests available, as it is able to pick up the presence of the virus even when there is much less of it present in the sample. Our Limit of Detection is between 50,000 and 200,000 viral copies per mL, whilst the Abbott BinaxNow test, for example, needs 1,000,000 viral copies per mL in order to get a positive signal.

Is it necessary to perform multiple tests to be sure of the result?

It should not be necessary to perform more than one test on a given individual at a single point in time, unless the KnowNowᵀᴹ device test results window displays no lines at all, meaning that the test has failed, or unless it was not possible to read the test results within 15 to 60 minutes of applying the mixed saliva and buffer solution to the KnowNowᵀᴹ device.

However, receiving a negative result does not mean that the individual tested can't be exposed to the SARS-CoV-2 virus following the test. So we do recommend that individuals are tested regularly to keep workplaces and communities safe. Depending on the scenario, we would recommend testing is repeated every 1 to 3 days.

What is a lateral flow test?

A lateral flow test is a simple diagnostic device designed to detect the presence or absence of a target substance in a liquid sample without the need for specialised and costly equipment.

The most commonly recognised type of lateral flow rapid test strip is the pregnancy test.

Had COVID - 19 symptoms in the last 2 days? Apply here to help us make testing accessible to all.