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Is it painful to take the KnowNowᵀᴹ Test?

No, not at all. It was really important to us when inventing this test, that it would be comfortable and easy enough that anyone would be happy to take a test every day if they needed to.

All the KnowNow test needs is a simple saliva sample from the mouth. Unlike alternative antigen tests or most PCR tests, the KnowNow test does not require the clinical professional to insert a swab very high inside the nose to collect a sample from the nasopharynx, nor does it require a tonsil swab. This is one COVID-19 test that won't make people gag or cry.

How long does a KnowNowᵀᴹ Test take?

The KnowNowᵀᴹ test will provide a result within 17-18 minutes of an individual arriving for their test.

The process of taking the saliva sample, mixing it with the buffer solution and dropping it onto the KnowNow test device should take a clinical professional no more than 2 to 3 minutes.

It then takes just 15 minutes for the test result to develop in the KnowNow device test results window.

The test result should not be read and interpreted after 60 minutes. If it wasn't possible to read and interpret the results between 15 and 60 minutes after dropping the solution into the sample well, the test should be discarded and the process repeated with another new test and saliva sample.

How big is a KnowNowᵀᴹ Test kit?

One box contains 25 tests, and measures 20cm (L) x 21cm (W) x 8cm (H).

Is it possible to tell if the test has been carried out incorrectly?

Failed KnowNowᵀᴹ Test Result
Failed KnowNowᵀᴹ Test Result

Yes, it will be very clear if the test has been carried out incorrectly and failed.

If there are no lines at all visible in the KnowNowᵀᴹ device test results window, then the test has failed, and it should be repeated with a new device and a fresh saliva sample.

Can anyone order KnowNowᵀᴹ Tests?

At the moment, KnowNowᵀᴹ Tests are for professional use only, meaning that they need to be administered by a trained healthcare professional. This means that we can take orders from organisations that have in-house or outsourced healthcare professionals who can perform the tests, or testing service providers.

However, since the KnowNowᵀᴹ Test needs just a saliva sample, it is much easier to administer effectively than other similar tests, and still return highly sensitive results. So we are investigating whether specially-trained, competent individuals could be approved to administer KnowNow tests as well.

We are also in the process of trialling and seeking approval for a variation of the KnowNow test which could be administered by individuals themselves.

Who is Vatic?

Vatic is a predictive health company focused on making medicine more proactive. We deliver on-the-spot tests which detect subtle biomarkers in people’s bodies to predict illness before it becomes acute or infectious.

Our first product is KnowNowᵀᴹ, a rapid turnaround COVID-19 antigen test, that is designed to identify COVID-positive people before they become highly infectious*, based on just a small saliva sample.

Is there a limit to how frequently I can take your tests?

No, there's no limit at all. KnowNow is specifically designed for frequent testing in order to offer the best chance of identifying infectious individuals as early as possible.

We recommend that individuals are tested as regularly as possible to keep workplaces and communities safe. Depending on the scenario, we would recommend that testing is performed every 2-3 days, or even daily, depending on the scenario.

How sensitive is the KnowNowᵀᴹ Test?

What’s important when it comes to sensitivity is how much virus needs to be present in the patient sample for the test to give a positive signal. This is known as the 'Limit of Detection', and we measure this rather than clinical sensitivity as it is much more informative.

Our Limit of Detection is between 50,000 and 200,000 viral copies per mL, making our test more sensitive than other rapid antigen tests available. The Abbott BinaxNow test, for example, needs 1,000,000 viral copies per mL in order to get a positive signal.

The KnowNowᵀᴹ Test's low Limit of Detection means it can detect infected people as early as day 3 to 4 of infection. This is before they become highly infectious, and a day or two earlier than most tests available (based on models of viral load in disease progression).

If you'd like to read more about this subject, we recommend reading this paper. It argues that the "Limit of Detection matters and directly impacts efforts to identify, control, and contain outbreaks during this pandemic" since "higher LoD are likely to miss nonnegligible fractions of infected individuals." It also makes the case that Limit of Detection values for tests using universal standard metrics should be readily available in the public domain to enable like-for-like comparison.

How should KnowNowᵀᴹ tests be stored?

KnowNowᵀᴹ Tests should be stored between 2 and 30 degrees celsius, which means it's fine to store it at room temperature in the UK's mild climate.

There's no need to store it inside a fridge, unless you're expecting extremely hot weather. If you do choose to refrigerate the test though, just make sure it comes to room temperature before using it.

The KnowNowᵀᴹ Test device should also be stored still sealed in its foil pouch. Once removed from the foil pouch, it should be used within one hour.

Are you taking shortcuts or risks by developing the KnowNowᵀᴹ Test so quickly?

No, we're not taking any shortcuts or risks. The KnowNowᵀᴹ test has been precisely developed, rigorously tested, and approved by the necessary bodies.

As with COVID vaccine development, the speed at which we’ve been able to move has been accelerated by the enhanced support and focus afforded to the sector by all stakeholders, such as the government, the pharmaceuticals industry, academic institutions and so on.

We have conducted two clinical studies. The first was a UK Government-based study across ten UK hospitals; the second was with Liverpool School of Tropical Medicine. We have also carried out our own analytical assessments, as well as two Public Health England analytical assessments.

The KnowNowᵀᴹ Test has been CE marked for professional use within a healthcare context and is approved by the UK's Medicines and Healthcare products Regulatory Agency (MHRA).

What is SARS-CoV-2?

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the name given by the International Committee on Taxonomy of Viruses (ICTV) to the virus responsible for causing the disease, COVID-19.

Had COVID - 19 symptoms in the last 2 days? Apply here to help us make testing accessible to all.